Modalert 200 mg interacts with Serotonin and GABA


Most people do not know that Modalert 200 mg and alcohol are not meant to be mixed. They often mix the two together without even thinking about it. Whether it is a student trying to study all night before an exam or a professional working on a stressful project, it is common for them to have a few drinks after work to unwind. Modalert is a cognitive enhancer and wakefulness agent that helps with issues like narcolepsy, obstructive sleep apnea, and excessive daytime sleepiness. It is also a popular hangover cure and can help prevent fatigue. Mixing this drug with alcohol can be dangerous for many reasons.

Both of these drugs influence the activity of several neurotransmitters including dopamine, norepinephrine, GABA, and glutamate. When taken on its own, Modalert 200 mg increases dopamine levels and inhibits the reuptake of other neurotransmitters. In contrast, alcohol influences the brain by increasing GABA activity and decreasing glutamate activity. Modafinil and alcohol affect the neurotransmitters in polar opposite ways, so they cannot be used at the same time.

The result is a tug of war-between the opposing brain chemistry. While the medication helps stimulate activity in one direction, the alcohol decreases brain activity in the other direction. This combination can cause a variety of symptoms, from dizziness to drowsiness to euphoria. Moreover, both substances promote water loss from the kidney and this can lead to dehydration.

Another issue is that the metabolites of Modalert and alcohol are excreted through the liver, which must work overtime to process the two substances. This can result in a toxic buildup of these compounds. The liver is also tasked with converting the active ingredients into inactive metabolites that are excreted into the urine or feces.

Combining Modalert with alcohol can also impact the body’s hormone production. In addition, the body may struggle to metabolize these substances due to the presence of other medications and alcohol. This can lead to side effects such as increased tolerance, blackouts, and a higher alcohol level than normal.


Modalert 200 mg and alcohol have polar opposite effects on the brain’s neurotransmitters GABA and glutamate. This is why it’s important not to mix them. GABA is the primary inhibitory neurotransmitter that keeps other neurotransmitters from firing in your brain. It helps regulate anxiety, sleep, and energy levels. It also improves learning and memory. However, too much GABA in the body can cause anxiety, depression, and drowsiness. Order Modafinil Australia is a GABA antagonist, meaning it decreases your brain’s production of GABA and boosts its synthesis of glutamate. This is why people who abuse Provigil by taking large doses of it and drinking are at a higher risk for blackouts and heightened alcohol tolerance.

Additionally, the process of breaking down Modalert 200 mg and alcohol in your body requires water, which means that mixing them together can lead to dehydration. This can further contribute to the negative side effects of Modalert and alcohol, such as gastrointestinal discomfort, dizziness, drowsiness, and headaches. The best way to avoid these adverse side effects is to not drink any alcohol at all if you’re going to take Modalert for any reason.

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